Innate T cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation

Among patients hospitalized for cardiac arrest (CA), most deaths are driven by neurological injury. Despite its clinical importance, there are no effective pharmacological therapies targeting post-CA neurological injury. In single-cell RNA-sequencing of peripheral blood mononuclear cells …

Reference

Tomoyoshi Tamura^*, Changde Cheng^*, Ana Villaseñor-Altamirano^*, Kei Hayashida, Kohei Ikeda^*, Kohei Yamada^*, Jaivardhan A Menon, Louis T. Merriam, Jack Varon, Jiyoung Choi, Aidan M. Cullen, Jingyu Guo, Benjamin A. Olenchock, Mayra A. Pinilla-Vera, Reshmi Manandhar, Muhammad Dawood Amir Sheikh, Peter C. Hou, Patrick R. Lawler, William M. Oldham, Raghu R. Seethala, Immunology of Cardiac Arrest Network (I-CAN), Rebecca M. Baron, Erin A. Bohula, David A. Morrow, Alexandra Weissman, Michael B. Brenner, Xiang Chen ‡ , Fumito Ichinose ‡ , Edy Y. Kim ‡ .; Innate T cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation